Entity
  • Lys Therapeutics

    Created in 2021
  • BETA

    Up & running (A)
    Existing signals show a regular activity
  • Social networks

    3,042
  • Activities

  • Technologies

  • Entity types

  • Location

    56 Rue Saint-Jean-de-Dieu, 69007 Lyon, France

    Lyon

    France

  • Employees

    Scale: 11-50

    Estimated: 12

  • SIREN

    895069904
  • Engaged corporates

    20
    5 14
  • Added in Motherbase

    1 year, 7 months ago
Description
  • Value proposition

    First-in-class biotherapies against neurological diseases.

    Targeting neuroinflammation to tackle neurodegeneration.

    Lys Therapeutics is a pioneering biotechnology company revolutionizing the treatment of patients with neurodegenerative or neurovascular diseases by targeting blood-brain barrier (BBB) dysfunctions and neuroinflammation.

    In the pathophysiology of various neurological diseases such as stroke, multiple sclerosis, and Parkinson's disease, the hyperactivation of endothelial NMDA receptors (NMDAr) by tissue plasminogen activator (tPA) overexpressed in these patients leads to the degradation of tight junctions and BBB dysfunction, allowing the transmigration of inflammatory cells and toxic molecules into the brain parenchyma, triggering excitotoxicity and neuroinflammation, major contributors to neurodegeneration.

    Lys Therapeutics' lead drug candidate, LYS241, is a first-in-class monoclonal antibody with a unique mechanism of action that effectively counteracts these pathological mechanisms. Specifically, LYS241 acts in blood vessels to prevent the binding of tPA to NMDAr without interfering with the physiological function of NMDAr. By inhibiting this interaction, NMDAr can function normally, and the activation of deleterious downstream cellular pathways is stopped. Tight junctions are restored, endothelial cells return to their healthy state, and BBB function is restored, protecting the brain from neuroinflammatory and neurodegenerative cascades.

    Lys Therapeutics' approach to targeting neuroinflammation to combat neurodegeneration represents a promising pathway in the quest for effective treatments for these debilitating disorders.

    Stroke, Multiple Sclerosis, Neurology, Neurodegenerative disorders, Healthcare, Biotechnology, Pharma, Drug development, Antibody, Parkinson, Parkinson's Disease, and Neurovascular diseases

  • Original language

    First-in-class biotherapies against neurological diseases.

    Targeting neuroinflammation to tackle neurodegeneration.

    Lys Therapeutics is a pioneering biotechnology company revolutionizing the treatment of patients with neurodegenerative or neurovascular diseases by targeting blood-brain barrier (BBB) dysfunctions and neuroinflammation.

    In the pathophysiology of various neurological diseases such as stroke, multiple sclerosis, and Parkinson's disease, the hyperactivation of endothelial NMDA receptors (NMDAr) by tissue plasminogen activator (tPA) overexpressed in these patients leads to the degradation of tight junctions and BBB dysfunction, allowing the transmigration of inflammatory cells and toxic molecules into the brain parenchyma, triggering excitotoxicity and neuroinflammation, major contributors to neurodegeneration.

    Lys Therapeutics' lead drug candidate, LYS241, is a first-in-class monoclonal antibody with a unique mechanism of action that effectively counteracts these pathological mechanisms. Specifically, LYS241 acts in blood vessels to prevent the binding of tPA to NMDAr without interfering with the physiological function of NMDAr. By inhibiting this interaction, NMDAr can function normally, and the activation of deleterious downstream cellular pathways is stopped. Tight junctions are restored, endothelial cells return to their healthy state, and BBB function is restored, protecting the brain from neuroinflammatory and neurodegenerative cascades.

    Lys Therapeutics' approach to targeting neuroinflammation to combat neurodegeneration represents a promising pathway in the quest for effective treatments for these debilitating disorders.

Corporate interactions BETA
Corporate TypeTweets Articles
Région Normandie
Région Normandie
National and local authorities, Government Administration
Région Normandie
National and local authorities, Government Administration
Other

25 Oct 2024


Région Auvergne-Rhône-Alpes
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National and local authorities, Government Administration
Région Auvergne-Rhône-Alpes
National and local authorities, Government Administration
Other

25 Oct 2024


Normandie Incubation
Normandie Incubation
Professional Training & Coaching
Normandie Incubation
Professional Training & Coaching
Other

28 Sep 2024


Ministère de la Santé Ministère de la Santé
Other

25 Sep 2024


Gouvernement Gouvernement
Other

25 Sep 2024


Ministère de l'Enseignement supérieur et de la Recherche Ministère de l'Enseignement supérieur et de la Recherche
Government Administration
Other

25 Sep 2024


Ministry of Economy
Ministry of Economy
Government Administration
Ministry of Economy
Government Administration
Other

25 Sep 2024


Biogen
Biogen
Biotechnology, Biotechnology Research
Biogen
Biotechnology, Biotechnology Research
Other

22 Mar 2024


La French Tech Saint-Etienne Lyon
La French Tech Saint-Etienne Lyon
French Tech, IT Services and IT Consulting
La French Tech Saint-Etienne Lyon
French Tech, IT Services and IT Consulting
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13 Mar 2024


PULSALYS
PULSALYS
Research, Research Services
PULSALYS
Research, Research Services
Other

23 Sep 2024


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